|
Mutation Information
|
Mutation Site
|
Y135F |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Nef |
|
Genotype/Subtype
|
B |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
30249546
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2018 |
|
Journal
|
EBioMedicine |
|
Title
|
Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 control. |
|
Author
|
Murakoshi H,Koyanagi M,Akahoshi T,Chikata T,Kuse N,Gatanaga H,Rowland-Jones SL,Oka S,Takiguchi M |
|
Evidence
|
However, the accumulation of an Y135F mutation in NefYF9 out of the 4 epitopes, which is selected by HLA-A*24:02-restricted T cells, affected the ability of YF9-specific T cells to suppress HIV-1 replication.
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HIV Mutation Detail Information