|
Mutation Information
|
Mutation Site
|
Y134N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
D |
|
Viral Reference
|
X85254.1;
M32138.1;
FJ904433.1;
AF121240.1;
X65259.1 |
|
Immune Escape
|
Y |
|
Country
|
Iran |
Literature Information
|
PubMed PMID
|
31105017
|
|
Disease
|
Hepatocellular carcinoma;
Liver cirrhosis;
HBV infection
|
|
Published Year
|
2019 |
|
Journal
|
Annals of hepatology |
|
Title
|
Association of HBsAg mutation patterns with hepatitis B infection outcome: Asymptomatic carriers versus HCC/cirrhotic patients. |
|
Author
|
Hosseini SY,Sanaei N,Fattahi MR,Malek-Hosseini SA,Sarvari J |
|
Evidence
|
RESULTS: The analysis of MHR and epitopes on HBsAg showed dozens of substitution, which occurred more prevalently in I110, P120, Y134, G159, S193, Y206, S207, I208, L213 and P214 positions. However, Y134N/F/L (P=0.04) and P120T/S (P=0.009) were significantly detected in MHR and B-cell epitope of HCC/Cirrhotic group.
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|
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HBV Mutation Detail Information