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Mutation Information
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Mutation Site
|
Y106F |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
LMP1 |
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Viral Reference
|
V01555.2
|
|
Country
|
Swiss |
Literature Information
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PubMed PMID
|
22384168
|
|
Disease
|
B-cell lymphoma;
T-cell lymphoma;
Hodgkin lymphoma
|
|
Published Year
|
2012 |
|
Journal
|
PloS one |
|
Title
|
Genetic diversity of EBV-encoded LMP1 in the Swiss HIV Cohort Study and implication for NF-Κb activation. |
|
Author
|
Zuercher E,Butticaz C,Wyniger J,Martinez R,Battegay M,Boffi El Amari E,Dang T,Egger JF,Fehr J,Mueller-Garamvögyi E,Parini A,Schaefer SC,Schoeni-Affolter F,Thurnheer C,Tinguely M,Telenti A,Rothenberger S,Swiss HIV Cohort Study. |
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Evidence
|
Interestingly, the single mutation F106Y in the context of B95-8 increases NF-kappaB activation level 3-fold, whereas in the context of chimeras P1118/B95-8 and A2118/B95-8 its effect is limited indicating that other polymorphisms located between amino acids 1 and 118 counteract this effect.
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EBV Mutation Detail Information