HIV Mutation Detail Information

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Mutation Information

Mutation Site	W666R
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Viral Reference	AAB50262.1

Literature Information

PubMed PMID	31504041
Published Year	2019
Journal	PloS one
Title	Identification of variant HIV envelope proteins with enhanced affinities for precursors to anti-gp41 broadly neutralizing antibodies.
Author	Zhu H,Mathew E,Connelly SM,Zuber J,Sullivan M,Piepenbrink MS,Kobie JJ,Dumont ME
Evidence	The distribution of sequences obtained from Next Generation Sequencing (NGS) of the population of cells following one round of sorting for 4E10 UCA binding confirmed the enrichment for W631R (present in 61% of reads), C605R (present in 11% of reads), W623R (present in 5% of reads), as well as revealing a surprising enrichment for additional Trp to Arg substitutions including W666R (present in two individual sorted clones and 3% of NGS reads), and W610R (present in two individual sorted clones and 2% of NGS reads).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation