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Mutation Information
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Mutation Site
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W631K |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Env |
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Viral Reference
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AAB50262.1
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Literature Information
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PubMed PMID
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31504041
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Published Year
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2019 |
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Journal
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PloS one |
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Title
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Identification of variant HIV envelope proteins with enhanced affinities for precursors to anti-gp41 broadly neutralizing antibodies. |
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Author
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Zhu H,Mathew E,Connelly SM,Zuber J,Sullivan M,Piepenbrink MS,Kobie JJ,Dumont ME |
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Evidence
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The significance of substituting a charged residue for W631 is further supported by the identification of W631K mutations at a frequency of 0.4% among total reads in the sorted 4E10 UCA-binding library and at a frequency of 1% among the reads that do not contain the W631R mutation, despite the fact that the W631K substitution requires a double base TGG→AAG substitution that is expected to occur at random at a frequency of only 0.0008% (calculated as the product of the frequencies in the unsorted library of the T→A substitution in the first position of the codon (0.4%) and G→A in the second position (0.2%)).
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HIV Mutation Detail Information