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Mutation Information
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Mutation Site
|
W28* |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PreC |
Literature Information
|
PubMed PMID
|
2304145
|
|
Disease
|
HBV infection
|
|
Published Year
|
1990 |
|
Journal
|
Journal of virology |
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Title
|
Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. |
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Author
|
Okamoto H,Yotsumoto S,Akahane Y,Yamanaka T,Miyazaki Y,Sugai Y,Tsuda F,Tanaka T,Miyakawa Y,Mayumi M |
|
Evidence
|
A point mutation from G to A at nucleotide 83, converting Trp-28 (TGG) to a stop codon (TAG), was by far the commonest and was observed in HBV DNA clones from 16 (89%) of 18 carriers seropositive for anti-HBe.
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HBV Mutation Detail Information