|
Mutation Information
|
Mutation Site
|
W28* |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PreC |
|
Amino acid_Mutation
|
G1896A |
|
Genotype/Subtype
|
D |
Literature Information
|
PubMed PMID
|
15328117
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2004 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine. |
|
Author
|
Tenney DJ,Levine SM,Rose RE,Walsh AW,Weinheimer SP,Discotto L,Plym M,Pokornowski K,Yu CF,Angus P,Ayres A,Bartholomeusz A,Sievert W,Thompson G,Warner N,Locarnini S,Colonno RJ |
|
Evidence
|
Patient B is a 55-year-old male who developed HBV disease recurrence following liver transplantation and who was HBV e antigen negative due to infection with precore-negative HBV (G1896A mutation resulting in a stop codon substitution for the codon corresponding to tryptophan at residue 28).
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HBV Mutation Detail Information