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HIV Mutation Detail Information

> W235F Search Result


Mutation Information
Mutation Site W235F
Mutation Type Amino acid level
Gene/Protein/Region Type IN
Literature Information
PubMed PMID 33980829
Published Year 2021
Journal Nature communications
Title INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication.
Author Dixit U,Bhutoria S,Wu X,Qiu L,Spira M,Mathew S,Harris R,Adams LJ,Cahill S,Pathak R,Rajesh Kumar P,Nguyen M,Acharya SA,Brenowitz M,Almo SC,Zou X,Steven AC,Cowburn D,Girvin M,Kalpana GV
Evidence We found that while the W235F mutant retained the interaction with INI1 as strongly as the wild type, W235K and W235E mutants showed reduced interactions in vitro (Supplementary Fig. 6b).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation