Mutation Information
Mutation Site
|
W235E |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
IN |
Literature Information
PubMed PMID
|
33980829
|
Published Year
|
2021 |
Journal
|
Nature communications |
Title
|
INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication. |
Author
|
Dixit U,Bhutoria S,Wu X,Qiu L,Spira M,Mathew S,Harris R,Adams LJ,Cahill S,Pathak R,Rajesh Kumar P,Nguyen M,Acharya SA,Brenowitz M,Almo SC,Zou X,Steven AC,Cowburn D,Girvin M,Kalpana GV |
Evidence
|
Interestingly, previous reports have indicated that W235E and W235K, but not W235F substitution mutations selectively inhibit integration activity in vivo but not in vitro
|
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