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Mutation Information
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Mutation Site
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W235A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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IN |
Literature Information
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PubMed PMID
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33980829
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Published Year
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2021 |
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Journal
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Nature communications |
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Title
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INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication. |
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Author
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Dixit U,Bhutoria S,Wu X,Qiu L,Spira M,Mathew S,Harris R,Adams LJ,Cahill S,Pathak R,Rajesh Kumar P,Nguyen M,Acharya SA,Brenowitz M,Almo SC,Zou X,Steven AC,Cowburn D,Girvin M,Kalpana GV |
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Evidence
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We tested the effect of a panel of IN-CTD substitution mutants from the IN-CTD/INI1183-304 interface, R228A, K244A, W235E, W235K, W235F, W235A and the two mutants K264A/K266A and R269A/K273A that have been shown to block IN/TAR binding for their ability to interact with INI1183-304 and TAR RNA at low salt conditions using Alpha assay
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HIV Mutation Detail Information