|
Mutation Information
|
Mutation Site
|
W199R |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
GQ872210
|
|
Relevant Drug
|
tenofovir |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
33562603
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2021 |
|
Journal
|
International journal of molecular sciences |
|
Title
|
Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes. |
|
Author
|
Lee AR,Cho JY,Kim JC,Dezhbord M,Choo SY,Ahn CH,Kim NY,Shin JJ,Park S,Park ES,Won J,Kim DS,Lee JH,Kim KH |
|
Evidence
|
Therefore, loss of HBsAg level in Clone 4-7, which has two additional mutations in polymerase compared to Clone 1-29, may be attributed to the S34P or/and W199R mutations in the corresponding surface gene.
|
|
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HBV Mutation Detail Information