HBV Mutation Detail Information

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Mutation Information
Mutation Site W196L
Mutation Type Amino acid level
Gene/Protein/Region Type S
Combined Mutation s.W196L+s.E164D
Immune Escape Y
Country China
Literature Information
PubMed PMID 28300730
Disease Chronic hepatitis B
Published Year 2017
Journal Antiviral therapy
Title The enrichment of HBV immune-escape mutations during nucleoside/nucleotide analogue therapy.
Author Shan M,Shen Z,Sun H,Zheng J,Zhang M
Evidence Three types of drug resistant mutations, single primary, multiple primary and primary plus compensatory mutations, were detected in a total of 97 patients of NAs treatment group, with rtM204I/V/S in YMDD motif being the most common substitution (78 of 97) (Table 2), which displays resistance to LMV and exerts sW196L/V and sI195M changes in the corresponding S protein.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation