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Mutation Information
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Mutation Site
|
W196L |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
S |
|
Country
|
Spain |
Literature Information
|
PubMed PMID
|
18167643
|
|
Disease
|
HBV-HIV coinfection
|
|
Published Year
|
2007 |
|
Journal
|
Journal of acquired immune deficiency syndromes (1999) |
|
Title
|
Selection of hepatitis B virus (HBV) vaccine escape mutants in HBV-infected and HBV/HIV-coinfected patients failing antiretroviral drugs with anti-HBV activity. |
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Author
|
Sheldon J,Ramos B,Garcia-Samaniego J,Rios P,Bartholomeusz A,Romero M,Locarnini S,Zoulim F,Soriano V |
|
Evidence
|
In contrast, 3TC-resistance-associated mutations rtV173L, rtM204V/I, and rtV207I may simultaneously alter the S gene, causing critical antigenic changes in the C terminal region of HBsAg, as a result of producing mutations sE164D, sI195M, sW196S/L/stop, and sM198I or sW199stop, respectively.
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HBV Mutation Detail Information