HBV Mutation Detail Information

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Mutation Information

Mutation Site	W196L
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	16928212
Disease	Chronic hepatitis B
Published Year	2006
Journal	Journal of gastroenterology and hepatology
Title	Association of core promoter mutations with viral breakthrough in chronic hepatitis B patients on long-term lamivudine therapy.
Author	Kazim SN,Chauhan R,Das BC,Sarin SK
Evidence	Well known lamivudine resistant rtYM204I/VDD mutations resulted in three types of mutations in the overlapping portions of the HBsAg encoded by S‐gene, that is, I195M (Fig.2d), W196L (Fig.2e) and W196Stop (Fig.2b) in these patients.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation