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Mutation Information
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Mutation Site
|
W196L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
rt.S223A+s.W196L+rt.M204I;s.W196L+rt.M204V;s.W196L+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
16830379
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2006 |
|
Journal
|
World journal of gastroenterology |
|
Title
|
Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs. |
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Author
|
Lu HY,Zeng Z,Xu XY,Zhang NL,Yu M,Gong WB |
|
Evidence
|
In our study, the change of methionine to isoleucine (rtM204I) or valine (rtM204V) was found in the YMDD motif of the polymerase gene protein in three patients who received long-term LMV therapy. These patients also had W196L/W196F or W199C mutations within the surface gene protein of HBV simultaneously.
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HBV Mutation Detail Information