|
Mutation Information
|
Mutation Site
|
W196L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
rt.M204I+s.W196L;s.S207R+s.W196L |
|
Amino acid_Mutation
|
G741T |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
India |
Literature Information
|
PubMed PMID
|
16428891
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2006 |
|
Journal
|
Intervirology |
|
Title
|
Characterization of naturally occurring and Lamivudine-induced surface gene mutants of hepatitis B virus in patients with chronic hepatitis B in India. |
|
Author
|
Kazim SN,Sarin SK,Sharma BC,Khan LA,Hasnain SE |
|
Evidence
|
Following lamivudine therapy, 14 of 57 (24.5%) patients developed 16 types of S-gene mutations (sP120S, sA128V, sS143L, sW182St., sT189I, sV190A, sS193L, sI195M, sW196L, sW196St., sS207R, sI208T, sS210E, sF219S, sF220L and sC221G).
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HBV Mutation Detail Information