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Mutation Information
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Mutation Site
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W172L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
S |
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Combined Mutation
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s.W172L+rt.A181T |
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Relevant Drug
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adefovir (ADV);entecavir (ETV) |
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Country
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China |
Literature Information
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PubMed PMID
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29630974
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Disease
|
HBV infection
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Published Year
|
2018 |
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Journal
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Antiviral research |
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Title
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Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation. |
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Author
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Zhao L,Li X,Cheng Y,Chen R,Shao J,Zhou Y,Li Q,Liao H,Zhao Y,Liu L,Su H,Liu Y,Liu Y,Xu D |
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Evidence
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RtA181T/sW172S + rtN236T and rtA181T/sW172L + rtN236T mutants exhibited higher HBV DNA production and adefovir resistance fold than that of rtA181T/sW172* + rtN236T mutant (98.02% and 85.5% vs. 42.1% in HBV DNA production, and 7.38-fold and 5.49-fold vs. 3.69-fold in half maximal effective concentration of wild-type strain); rtA181T/sW172L + rtS202G + rtM204V strain exhibited higher HBV DNA production and entecavir resistance fold than that of rtA181T/sW172* + rtS202G + rtM204V strain (50.98% vs. 34.49%, 524.00-fold vs. 69.33-fold).
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HBV Mutation Detail Information