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Mutation Information
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Mutation Site
|
W172L |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
S |
|
Combined Mutation
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s.W172L+rt.A181T;rt.N236T+s.W172L+rt.A181T |
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Relevant Drug
|
tenofovir (TDF);adefovir (ADV) |
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Country
|
USA |
Literature Information
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PubMed PMID
|
24118725
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Disease
|
HBV infection
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Published Year
|
2014 |
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Journal
|
Liver international : official journal of the International Association for the Study of the Liver |
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Title
|
HBV clinical isolates expressing adefovir resistance mutations show similar tenofovir susceptibilities across genotypes B, C and D. |
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Author
|
Liu Y,Miller MD,Kitrinos KM |
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Evidence
|
One mutant resulted in a stop codon at HBsAg position 172 (rtA181T/sW172*), whereas the other mutant resulted in an amino acid change at HBsAg position 172 (rtA181T/sW172L). The rtA181T/sW172L + rtN236T and rtA181V + rtN236T double mutants were created by two rounds of mutagenesis.
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HBV Mutation Detail Information