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Mutation Information
|
Mutation Site
|
W172C |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Genotype/Subtype
|
A |
|
Immune Escape
|
Y |
|
Country
|
Spain |
Literature Information
|
PubMed PMID
|
22666402
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2012 |
|
Journal
|
PloS one |
|
Title
|
Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome. |
|
Author
|
Rodriguez-Frías F,Tabernero D,Quer J,Esteban JI,Ortega I,Domingo E,Cubero M,Camós S,Ferrer-Costa C,Sánchez A,Jardí R,Schaper M,Homs M,Garcia-Cehic D,Guardia J,Esteban R,Buti M |
|
Evidence
|
These 20 variants did not include the immune escape variant sG145R, detected in relatively high frequencies at pre-treatment, but otherwise included the variants sS167L, sW172C, and sW172*, located at the minimal recognized sequence (positions s165 to s172) of the TH-s156/s175 epitope [27]; among these, sS167L showed a continuous percentage increase from pre-treatment to ETV-VBK (sample 4A: 0.2%, 4B: 0.7%, 4C: 1.1%, 4D: 1.3%, 4E: 4%).
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|
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HBV Mutation Detail Information