HBV Mutation Detail Information

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Mutation Information

Mutation Site	W172*
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Combined Mutation	s.W172*+rt.A181T
Genotype/Subtype	C
Relevant Drug	adefovir (ADV);adefovir dipivoxil (ADV)

Literature Information

PubMed PMID	26201776
Published Year	2013
Journal	Hepatology international
Title	Hepatitis B virus genotype C encoding resistance mutations that emerge during adefovir dipivoxil therapy: in vitro replication phenotype.
Author	Li W,Warner N,Sozzi V,Yuen L,Colledge D,Li T,Zhuang H,Locarnini S,Revill PA
Evidence	We have recently shown that for HBV genotype D, the rtA181T/sW172stop substitution conferring resistance to adefovir dipivoxil (ADV) alters secretion of HBsAg and exerts a dominant-negative effect on wild-type virion secretion.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation