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Mutation Information
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Mutation Site
|
W172* |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.W172*+rt.A181T |
|
Relevant Drug
|
tenofovir (TDF);adefovir (ADV) |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
24118725
|
|
Disease
|
HBV infection
|
|
Published Year
|
2014 |
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Journal
|
Liver international : official journal of the International Association for the Study of the Liver |
|
Title
|
HBV clinical isolates expressing adefovir resistance mutations show similar tenofovir susceptibilities across genotypes B, C and D. |
|
Author
|
Liu Y,Miller MD,Kitrinos KM |
|
Evidence
|
One mutant resulted in a stop codon at HBsAg position 172 (rtA181T/sW172*), whereas the other mutant resulted in an amino acid change at HBsAg position 172 (rtA181T/sW172L). The rtA181T/sW172L + rtN236T and rtA181V + rtN236T double mutants were created by two rounds of mutagenesis.
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HBV Mutation Detail Information