Mutation Information
Mutation Site
|
W172* |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
S |
Genotype/Subtype
|
A |
Country
|
Spain |
Literature Information
PubMed PMID
|
22666402
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2012 |
Journal
|
PloS one |
Title
|
Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome. |
Author
|
Rodriguez-Frías F,Tabernero D,Quer J,Esteban JI,Ortega I,Domingo E,Cubero M,Camós S,Ferrer-Costa C,Sánchez A,Jardí R,Schaper M,Homs M,Garcia-Cehic D,Guardia J,Esteban R,Buti M |
Evidence
|
Of note, a substantial part of these substitutions (4 out of 9) resulted in stop codons (*) (sW156*, sW163*, sW165* and sW172*), giving rise to proteins with significant aa deletions.
|
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