Mutation Information
Mutation Site
|
V90I |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Relevant Drug
|
NNRTIs |
Country
|
South Africa |
Literature Information
PubMed PMID
|
32071061
|
Disease
|
HIV infection/AIDS
|
Published Year
|
2020 |
Journal
|
Antimicrobial agents and chemotherapy |
Title
|
Discordance between Etravirine Phenotype and Genotype-Based Predicted Phenotype for Subtype C HIV-1 from First-Line Antiretroviral Therapy Failures in South Africa. |
Author
|
McCormick KD,Penrose KJ,Brumme CJ,Harrigan PR,Viana RV,Mellors JW,Parikh UM,Wallis CL |
Evidence
|
HIV-1 subtype C donor-derived viruses with V90I (P < 0.024) and V179D (P < 0.007) also showed a trend toward increased ETR resistance, but when adjusted for multiple comparisons (q < 0.567 and q < 0.233, respectively), these were no longer significant.
|
|
|