HTLV1 Mutation Detail Information

> V89A Search Result

Mutation Information

Mutation Site	V89A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Tax

Literature Information

PubMed PMID	19356250
Published Year	2009
Journal	Retrovirology
Title	Induction of p21(CIP1/WAF1) expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization.
Author	Zhang L,Zhi H,Liu M,Kuo YL,Giam CZ
Evidence	To further elucidate the mechanism by which Tax up-regulates p21 expression, we analyzed APC/C-deficient mutants L235F and A108T along with three well-characterized tax mutants: M22, M47, and V89A that had been shown to be impaired, respectively, in NF-kappaB activation, LTR trans-activation, and CBP/p300-binding and LTR trans-activation.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation