|
Mutation Information
|
Mutation Site
|
V85L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Nef |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
K03455.1
|
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
17311088
|
|
Clinical information
|
Yes
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2007 |
|
Journal
|
PloS one |
|
Title
|
Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape. |
|
Author
|
Karlsson AC,Iversen AK,Chapman JM,de Oliviera T,Spotts G,McMichael AJ,Davenport MP,Hecht FM,Nixon DF |
|
Evidence
|
In the last sample, drawn at week 158, the major population (13/14 clones) carried two new mutations, A83G and V85L, while the position 87 had reverted back to a wild type leucine, and new, less prevalent HLA-A2-restricted CTL responses towards these variants could be detected.
|
|
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HIV Mutation Detail Information