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Mutation Information
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Mutation Site
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V82I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
PR |
Literature Information
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PubMed PMID
|
31172041
|
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Published Year
|
2019 |
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Journal
|
ACS omega |
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Title
|
Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues. |
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Author
|
Agniswamy J,Kneller DW,Brothers R,Wang YF,Harrison RW,Weber IT |
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Evidence
|
The co-occurrence of flap mutations like G48V that block P3 substrate-binding site and large substitutions at residue 82 like V82F, V82L, and V82I that block the alternate P3 binding site are expected to be detrimental to PR activity.
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HIV Mutation Detail Information