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Mutation Information
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Mutation Site
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V82I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
PR |
Literature Information
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PubMed PMID
|
25362963
|
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Published Year
|
2014 |
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Journal
|
Scientific reports |
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Title
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Revealing origin of decrease in potency of darunavir and amprenavir against HIV-2 relative to HIV-1 protease by molecular dynamics simulations. |
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Author
|
Chen J,Liang Z,Wang W,Yi C,Zhang S,Zhang Q |
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Evidence
|
The decrease in binding free energies for PR2 relative to PR1 is found to arise from the reduction of the van der Waals interactions induced by the structural adjustment of the triple mutant V32I, I47V and V82I.
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HIV Mutation Detail Information