Mutation Information
Mutation Site
|
V82F |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
PR |
Literature Information
PubMed PMID
|
33175558
|
Published Year
|
2020 |
Journal
|
Langmuir : the ACS journal of surfaces and colloids |
Title
|
Multiple Molecular Dynamics Simulations of the Inhibitor GRL-02031 Complex with Wild Type and Mutant HIV-1 Protease Reveal the Binding and Drug-Resistance Mechanism. |
Author
|
Wang R,Zheng Q |
Evidence
|
For instance, compared with the WT PR, L90M and V82F/I84V mutations cause the flaps to be more open,(60,61) while M46I and I50L/A71V mutations cause the flaps to be more closed.
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