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Mutation Information
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Mutation Site
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V82F |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
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Relevant Drug
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darunavir (DRV) |
Literature Information
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PubMed PMID
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27992544
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Published Year
|
2016 |
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Journal
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PloS one |
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Title
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Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics. |
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Author
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Agniswamy J,Louis JM,Roche J,Harrison RW,Weber IT |
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Evidence
|
This inactive protease with active site D25N mutation has 22 other mutations (L10I, V11I, L23I, V32I, L33F, S37N, M46I, I47V, I50V, F53L, I54V, Q58E, D60E, L63P, H69R, A71V, G73S, V77I, V82F, L89V, L90M, I93L) including 6 DRV resistance mutations (V11I, V32I, L33F, I47V, I50V, L89V).
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HIV Mutation Detail Information