HIV Mutation Detail Information

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Mutation Information
Mutation Site V82A
Mutation Type Amino acid level
Gene/Protein/Region Type PR
Literature Information
PubMed PMID 33314454
Published Year 2021
Journal Protein science : a publication of the Protein Society
Title A synergy of activity, stability, and inhibitor-interaction of HIV-1 protease mutants evolved under drug-pressure.
Author Khan SN,Persons JD,Guerrero M,Ilina TV,Oda M,Ishima R
Evidence A clinically-relevant, drug-resistant mutant of HIV-1 protease (PR), termed Flap+(I54V) and containing L10I, G48V, I54V and V82A mutations, is known to produce significant changes in the entropy and enthalpy balance of drug-PR interactions, compared to wild-type PR.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation