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Mutation Information
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Mutation Site
|
V82A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
PIs |
|
Country
|
Africa |
Literature Information
|
PubMed PMID
|
30891603
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
High predictive efficacy of integrase strand transfer inhibitors in perinatally HIV-1-infected African children in therapeutic failure of first- and second-line antiretroviral drug regimens recommended by the WHO. |
|
Author
|
Mboumba Bouassa RS,Mossoro-Kpinde CD,Gody JC,Veyer D,Péré H,Matta M,Robin L,Grésenguet G,Charpentier C,Bélec L |
|
Evidence
|
DRMs to PIs corresponded mainly to natural polymorphism in the P gene while only the major DRMs V82A/F (n = 3;20%) and L33F (n = 1, 6.7%) could be found. The majority of genotyped viruses harboured at least one mutation associated with NNRTI resistance (85.7%) or with NRTI resistance (78.5%).
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HIV Mutation Detail Information