|
Mutation Information
|
Mutation Site
|
V75I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
B;C |
|
Relevant Drug
|
NRTIs;tenofovir (TDF) |
|
Country
|
Zambia |
Literature Information
|
PubMed PMID
|
21569325
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2011 |
|
Journal
|
Retrovirology |
|
Title
|
The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains. |
|
Author
|
Mbisa JL,Gupta RK,Kabamba D,Mulenga V,Kalumbi M,Chintu C,Parry CM,Gibb DM,Walker SA,Cane PA,Pillay D |
|
Evidence
|
The emergence of Q151M MDR occurred in the order A62V, V75I, and finally Q151M on the same genome at 4, 17 and 37 months after initiation of therapy, respectively.
|
|
|
HIV Mutation Detail Information