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Mutation Information
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Mutation Site
|
V70A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E6 |
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Genotype/Subtype
|
HPV5 |
Literature Information
|
PubMed PMID
|
30875834
|
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Published Year
|
2019 |
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Journal
|
Cells |
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Title
|
The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene. |
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Author
|
Taute S,Böhnke P,Sprissler J,Buchholz S,Hufbauer M,Akgül B,Steger G |
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Evidence
|
The P40A, V70A and L63A/W65A mutants in HPV5E6, which correspond to P38A, L61A/W63A and V68A in HPV8E6, respectively, lost completely their activity to induce the degradation of Bak, but still partially inhibited apoptosis, indicating that other activities than targeting Bak may contribute to HV8E6-mediated inhibition of UV-induced apoptosis.
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HPV Mutation Detail Information