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Mutation Information
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Mutation Site
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V518I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
Literature Information
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PubMed PMID
|
24211331
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Published Year
|
2014 |
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Journal
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Antiviral research |
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Title
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Molecular mechanism of HIV-1 resistance to 3'-azido-2',3'-dideoxyguanosine. |
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Author
|
Meteer JD,Schinazi RF,Mellors JW,Sluis-Cremer N |
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Evidence
|
We reported that 3'-azido-2',3'-dideoxyguanosine (3'-azido-ddG) selected for the L74V, F77L, and L214F mutations in the polymerase domain and K476N and V518I mutations in the RNase H domain of HIV-1 reverse transcriptase (RT).
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HIV Mutation Detail Information