HIV Mutation Detail Information

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Mutation Information

Mutation Site	V488I
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120
Viral Reference	K03455.1

Literature Information

PubMed PMID	24758333
Published Year	2014
Journal	Retrovirology
Title	Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site.
Author	Utachee P,Isarangkura-na-ayuthaya P,Tokunaga K,Ikuta K,Takeda N,Kameoka M
Evidence	Ten positions were found to be different between b12-susceptible 47PL1 and b12-resistant 47CC11 (Figure 2, asterisks). Therefore, a series of point mutations, H144L, G185D, N189S, I190T, N301Q, I467T, V488I, R500M, del.NIND (deletion of 4 amino acid residues, NIND in the V2 region of gp120) (Figure 2) or ins.D460 (insertion of an amino acid residue D460) was introduced into 47CC11-N197Q, and recombinant viruses containing these AE-Env mutants were subjected to neutralization tests.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation