HIV Mutation Detail Information

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Mutation Information

Mutation Site	V430A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120

Literature Information

PubMed PMID	23011758
Published Year	2013
Journal	Proteins
Title	HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism.
Author	Tuzer F,Madani N,Kamanna K,Zentner I,LaLonde J,Holmes A,Upton E,Rajagopal S,McFadden K,Contarino M,Sodroski J,Chaiken I
Evidence	KR21-alphabt binding to WT and mutant gp120To validate the effects of the mutations first tested in the ELISA based inhibition assays and of two new mutants (V255A and V430A) that became available after the ELISA screen, we used an SPR based secondary screen to rank these mutants according to their binding affinity and inhibition by the biotinylated PT KR21 (Fig.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation