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Mutation Information
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Mutation Site
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V3I |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
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Relevant Drug
|
atazanavir (ATV);darunavir (DRV);indinavir (IDV);lopinavir (LPV);nelfinavir (NFV);saquinavir (SQV);tipranavir (TPV) |
Literature Information
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PubMed PMID
|
28155724
|
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Published Year
|
2016 |
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Journal
|
BMC bioinformatics |
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Title
|
Structural analyses of 2015-updated drug-resistant mutations in HIV-1 protease: an implication of protease inhibitor cross-resistance. |
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Author
|
Su CT,Ling WL,Lua WH,Haw YX,Gan SK |
|
Evidence
|
In the three wild type protease-PI complexes: DRV_0, LPV_0, and NFV_0, naturally occurring single residue substitutions S37N, L63P, and V3I, respectively, were found to shrink the PI-binding pocket (~30% decrease in DRV_0 and LPV_0, and ~10% decrease in NFV_0).
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HIV Mutation Detail Information