HIV Mutation Detail Information

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Mutation Information

Mutation Site	V38A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp41
Relevant Drug	enfuvirtide (T20)
Country	Spain

Literature Information

PubMed PMID	22333046
Clinical information	Yes
Disease	HIV infection/AIDS
Published Year	2012
Journal	Retrovirology
Title	The HR2 polymorphism N140I in the HIV-1 gp41 combined with the HR1 V38A mutation is associated with a less cytopathic phenotype.
Author	Cunyat F,Marfil S,García E,Svicher V,Pérez-Alvárez N,Curriu M,Perno CF,Clotet B,Blanco J,Cabrera C
Evidence	The HR2 polymorphism N140I in the HIV-1 gp41 combined with the HR1 V38A mutation is associated with a less cytopathic phenotypeResistance to the fusion inhibitor enfuvirtide (ENF) is achieved by changes in the gp41 subunit of the HIV envelope glycoprotein (Env).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation