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Mutation Information
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Mutation Site
|
V370M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gag |
|
Relevant Drug
|
GSK3532795 |
Literature Information
|
PubMed PMID
|
31622432
|
|
Published Year
|
2019 |
|
Journal
|
PloS one |
|
Title
|
Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study. |
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Author
|
Dicker I,Zhang S,Ray N,Beno BR,Regueiro-Ren A,Joshi S,Cockett M,Krystal M,Lataillade M |
|
Evidence
|
In addition, one participant who lost a V370M mutation at Day 14 (#44;40 mg dose group), susceptibility was significantly increased with a decrease in FC-IC50 from 132 at Day 10 to 0.48 at Day 14.
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HIV Mutation Detail Information