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Mutation Information
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Mutation Site
|
V32I |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
|
Viral Reference
|
K03455.1
|
|
Relevant Drug
|
PIs |
Literature Information
|
PubMed PMID
|
17227139
|
|
Published Year
|
2007 |
|
Journal
|
PLoS medicine |
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Title
|
A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism. |
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Author
|
Nijhuis M,van Maarseveen NM,Lastere S,Schipper P,Coakley E,Glass B,Rovenska M,de Jong D,Chappey C,Goedegebuure IW,Heilek-Snyder G,Dulude D,Cammack N,Brakier-Gingras L,Konvalinka J,Parkin N,Kräusslich HG,Brun-Vezinet F,Boucher CA |
|
Evidence
|
In three of the experiments we observed an A431V amino acid substitution in the NC/p1 cleavage site, combined with known resistance substitutions in protease (V32I, M46I/L, I54V, V82A/F, and I84V).
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HIV Mutation Detail Information