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Mutation Information
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Mutation Site
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V247I |
|
Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Gp46 |
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Country
|
Brazil |
Literature Information
|
PubMed PMID
|
23510700
|
|
Disease
|
HTLV-1 associated myelopathy/tropical spastic paraparesis
|
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Published Year
|
2013 |
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Journal
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Virology journal |
|
Title
|
Molecular characterization of HTLV-1 gp46 glycoprotein from health carriers and HAM/TSP infected individuals. |
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Author
|
Mota-Miranda AC,Barreto FK,Amarante MF,Batista E,Monteiro-Cunha JP,Farre L,Galvão-Castro B,Alcantara LC |
|
Evidence
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In conclusion, the results presented in this study suggest that the most frequent gp46 mutations (F14S, N42H, V247I and S35L), as well as, the mutations (H290D, C289R, F141S, D197N and F159S) associated to the loss of a post-translational site should be evaluated in greater detail, in particular the reactivity of the mutated proteins against natural antibodies.
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HTLV1 Mutation Detail Information