HBV Mutation Detail Information

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Mutation Information

Mutation Site	V190A
Mutation Type	Amino acid level
Gene/Protein/Region Type	S
Combined Mutation	s.F220L+s.V190A
Genotype/Subtype	D
Viral Reference	X65259.1
Country	Italy; United Kingdom and Germany

Literature Information

PubMed PMID	32312174
Disease	Chronic hepatitis B
Published Year	2020
Journal	Emerging microbes & infections
Title	Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection.
Author	Salpini R,Battisti A,Piermatteo L,Carioti L,Anastasiou OE,Gill US,Di Carlo D,Colagrossi L,Duca L,Bertoli A,La Rosa KY,Fabeni L,Iuvara A,Malagnino V,Cerva C,Lichtner M,Mastroianni CM,De Sanctis GM,Paoloni M,Marignani M,Pasquazzi C,Iapadre N,Parruti G,Vecchiet J,Sarmati L,Andreoni M,Angelico M,Grelli S,T Kennedy P,Verheyen J,Aquaro S,Silberstein FC,Perno CF,Svicher V
Evidence	In genotype-D, specific C-terminus mutations (V190A-S204N-Y206C-Y206F-S210N) significantly correlate with HBsAg<1000IU/ml(P-value from <0.001 to 0.04).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation