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Mutation Information

Mutation Site	V148L
Mutation Type	Amino acid level
Gene/Protein/Region Type	Nef
Country	Netherlands

Literature Information

PubMed PMID	33800773
Disease	HIV infection/AIDS
Published Year	2021
Journal	Viruses
Title	Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction.
Author	Kruize Z,van Nuenen AC,van Wijk SW,Girigorie AF,van Dort KA,Booiman T,Kootstra NA
Evidence	Previous reports indicated that some naturally occurring mutations in Nef could affect both SERINC3 and SERINC5 (N51T, H116N, V148L/X, 161N and M168I/X), while others only affected SERINC3 (8R, 9S, 11P, 12G, 14A, 15A, 21K, 28E, 43I, 182E and 188S) or SERINC5 (14S, 21R, 54D, 63E, 81F, 120F, 157N and 158K).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation