HIV Mutation Detail Information

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Mutation Information

Mutation Site	V13A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Vif
Combined Mutation	vif.V13A+vif.Q12A

Literature Information

PubMed PMID	28302150
Published Year	2017
Journal	Retrovirology
Title	Identification of a tripartite interaction between the N-terminus of HIV-1 Vif and CBFβ that is critical for Vif function.
Author	Desimmie BA,Smith JL,Matsuo H,Hu WS,Pathak VK
Evidence	Finally, we also observed that N3A-R4A, Q12A-V13A, M16A-R17A, N19A-T20A, and R23A-L24A mutants exhibited a significantly higher efficiency of binding to CBFbeta compared to WT Vif (Fig. 1b;values indicated in red);the potential biological significance of increased binding to CBFbeta by these mutants was not further examined in these studies.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation