|
Mutation Information
|
Mutation Site
|
V131L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
X |
|
Combined Mutation
|
x.V131L+x.K130M+x.I127T |
|
Genotype/Subtype
|
D |
|
Viral Reference
|
X04615.1
|
|
Country
|
Saudi Arabia |
Literature Information
|
PubMed PMID
|
29285238
|
|
Disease
|
Liver cirrhosis;
Hepatocellular carcinoma
|
|
Published Year
|
2017 |
|
Journal
|
Oncotarget |
|
Title
|
Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients. |
|
Author
|
Al-Qahtani AA,Al-Anazi MR,Nazir N,Ghai R,Abdo AA,Sanai FM,Al-Hamoudi WK,Alswat KA,Al-Ashgar HI,Khan MQ,Albenmousa A,Cruz DD,Bohol MFF,Al-Ahdal MN |
|
Evidence
|
One double mutation (K130M+V131I) and two triple mutations (I127T+K130M+V131L and K130M+V131I+F132Y) were observed, with significant rising prevalence through progressive clinical phases of liver disease to HCC.
|
|
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HBV Mutation Detail Information