HIV Mutation Detail Information

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Mutation Information

Mutation Site	V106A
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.V106A+rt.F227L

Literature Information

PubMed PMID	33979774
Published Year	2021
Journal	Bioorganic & medicinal chemistry
Title	Design, synthesis and anti-HIV evaluation of novel 5-substituted diarylpyrimidine derivatives as potent HIV-1 NNRTIs.
Author	Gao P,Song S,Wang Z,Sun L,Zhang J,Pannecouque C,De Clercq E,Zhan P,Liu X
Evidence	All the synthesized compounds were evaluated for their activity against WT HIV-1 (strain HIV-IIIB), double RT mutant strain HIV-1 IIIB (RES056 and F227L/V106A), five single RT mutant strain HIV-1 IIIB (L100I, K103N, E138K, Y181C, Y188L), and HIV-2 (strain ROD) in MT-4 cells by using MTT method described previously.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation