HIV Mutation Detail Information

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Mutation Information

Mutation Site	V106A
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.V106A+rt.F227L

Literature Information

PubMed PMID	32977301
Published Year	2020
Journal	European journal of medicinal chemistry
Title	Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility.
Author	Wang Z,Kang D,Feng D,Cherukupalli S,Jiang X,Fu Z,De Clercq E,Pannecouque C,Liu X,Zhan P
Evidence	More encouragingly, 14d2 (RF = 0.4) possessed higher antiresistance profile than ETV (RF = 6.3) and K-5a2 (RF = 3.0) toward the double mutant strain F227L + V106A.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation