HIV Mutation Detail Information

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Mutation Information

Mutation Site	T97A
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Genotype/Subtype	B
Relevant Drug	INSTIs

Literature Information

PubMed PMID	30568974
Disease	HIV infection/AIDS
Published Year	2018
Journal	Open forum infectious diseases
Title	Rapid Development of High-Level Resistance to Dolutegravir With Emergence of T97A Mutation in 2 Treatment-Experienced Individuals With Baseline Partial Sensitivity to Dolutegravir.
Author	George JM,Kuriakose SS,Dee N,Stoll P,Lalani T,Dewar R,Khan MA,Rehman MT,Grossman Z,Maldarelli F,Pau AK
Evidence	Rapid Development of High-Level Resistance to Dolutegravir With Emergence of T97A Mutation in 2 Treatment-Experienced Individuals With Baseline Partial Sensitivity to DolutegravirHIV integrase mutation T97A emerges after suboptimal therapy with integrase strand transfer inhibitors (INSTIs), but the contribution of T97A to dolutegravir resistance remains uncertain.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation