HBV Mutation Detail Information

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Mutation Information

Mutation Site	T895A
Mutation Type	Nucleotide level
Gene/Protein/Region Type	P
Nucleotide_Mutation	C620S (rtC256S)
Viral Reference	EU871982.1
Country	China

Literature Information

PubMed PMID	24788140
Disease	Hepatocellular carcinoma
Published Year	2014
Journal	PloS one
Title	Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.
Author	Wu Y,Gan Y,Gao F,Zhao Z,Jin Y,Zhu Y,Sun Z,Wu H,Chen T,Wang J,Sun Y,Fan C,Xiang Y,Qian G,Groopman JD,Gu J,Tu H
Evidence	Because this study aimed to investigate the effect of RT mutations on HCC, we then selected 11 mutations (A799G, T843C, T870C, T895A, T906R, C936T, A942S, A987G, T1055A, T1069A, and T1071C) that did not affect HBsAg function as candidates for further validation assays.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation