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Mutation Information
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Mutation Site
|
T76E |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
E7 |
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Combined Mutation
|
e7.T74A+e7.T76E |
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Genotype/Subtype
|
HPV58 |
Literature Information
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PubMed PMID
|
30575267
|
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Published Year
|
2019 |
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Journal
|
Journal of cellular and molecular medicine |
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Title
|
Oncogenic comparison of human papillomavirus type 58 E7 variants. |
|
Author
|
Law PT,Boon SS,Hu C,Lung RW,Cheung GP,Ho WC,Chen Z,Massimi P,Thomas M,Pim D,Banks L,Chan PK |
|
Evidence
|
Consistently, we observed that V1A (T20I) and V1B (G63S) can degrade pRb at a similar level as V2 (G43R/G63D) and V3 (T74A/T76E), even though at a weaker extent compared to V1 (T20I/G63S).
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HPV Mutation Detail Information